Scientific publications

Potential therapeutic properties of Aronia melanocarpa

 Effects on cardiovascular system:

  1. Niedworok J., Therapeutical properties of anthocyanins from Aronia melancarpa. Farm. Pol., 2001; 57: 719-721.
  2. Kowalczyk E., Kopff A., Niedworok J., Kopff M., Jankowski A.: Anthocyanins –an adjunct to cardiovascular therapy? Kardiol. Pol., 2002; 57: 332-336.
  3. Naruszewicz M., Daniewski M.,ŁaniewskaI., Pikto-Pietkiewicz W., Millo B., Zapolska-Downar D.: Effect of anthocyanins from chokeberry (Aronia melanocarpa) on blood pressure, inflammatory mediators and cell adhesion molecules in patients with a history of myocardial infarction (MI). Atherosclerosis Suppl, 2003; 4: 143.
  4. Rechner A.R., Kroner C.: Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function. Thromb. Res., 2005; 116: 327-334.
  5. Oszmiański J., Wojdyło A.: Aronia melanocarpa phenolics and their antioxidant activity. Eur. Food Res. Technol., 2005; 221: 809-813.
  6. Zapolska-Downar D, Kosmider A, Naruszewicz M. : Flavonoids-rich extract from chokeberry fruits inhibits oxLDL-induced apoptosis of endothelial cells. Atherosclerosis Suppl, 2006; 7: 223.
  7. Ryszawa N., Kawczyńska-Dróżdż A., Pryjma J., Cześnikiewicz-Guzik M., Adamek-Guzik T., Naruszewicz M., Korbut R., Guzik T.J.: Effects of novel plant antioxidants on platelet superoxide production and aggregation in atherosclerosis. J. Physiol. Pharmacol., 2006; 57: 611-626.
  8. Bell D.R., Gochenaur K.: Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J. Appl. Physiol., 2006; 100: 1164-1170.
  9. Vita J.A.: Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am. J. Clin. Nutr., 2007; 29: 292-297.
  10. Bell D.R., Burt T.D.: Phenolic acids contained in anthocyanin enriched extracts from elderberry, bilberry and chokeberry possess endothelium dependent and independent vasorelaxation properties in porcine coronary arteries. Faseb. J., 2007; 21: 366.
  11. Sesso H.D., Gaziano M.J., Liu S., E Buring J.E.: Flavonoid intake and the risk of cardiovascular disease in women. Am. J. Clin. Nutr., 2007; 29: 1400-1408.
  12. Andriambeloson E., Magnier C., Haan-Archipoff G., Lobstein A, Anton R., Beretz A., Stoclet J.C., Andriantsitohaina R.: Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J. Nutr., 2007; 29: 2324-2333.
  13. Mazza G.J.: Anthocyanins and heart health. Ann. Ist. Super Sanita. 2007;43: 369-374
  14. Galvano F.,La Fauci L.,Vitaglione P., Fogliano V., Vanella L., Felgines C.: Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. Ann. Ist. Super Sanita., 2007; 43: 382-93.
  15. Naruszewicz M.,ŁaniewskaI., Millo B., Dłużniewski M.: Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI). Atherosclerosis, 2007; 194: 179-184.
  16. Olas B., Wachowicz B., Tomczak A., Erler J., Stochmal A., Oleszek W.: Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets, 2008; 19: 70-77.
  17. Zapolska-Downar D, Nowicka G, Sygitowicz G, Jarosz M.: Anthocyanin-rich Aronox extract from Aronia melanocarpa E protects against 7beta- hydroxycholesterol – induced apoptosis of endothelial cells. Ann. Nutr. Metab., 2008; 53: 283-294.
  18. Poręba R., Skoczyńska A., Gać P., Poręba M.,JedrychowskaI., Affelska-Jercha A., Turczyn B., Wojakowska A., Oszmiański J., Andrzejak R.: Drinking of chokeberry juice from the ecological farm Dzięciołowo and distensibility of brachial artery in men with mild hypercholesterolemia. Ann. Agric. Environ. Med., 2009; 16: 305-308.
  19. Luzak B., Golański J., Rozalski M., Karejwska U., Olas B., Watala C.: Extract from Aronia melanocarpa fruits potentiates the inhibitor of platelet in the presence of endothelial cells. Arch. Med. Sci., 2010; 6: 141-144.
  20. Basu A, Rhone M, Lyons T.J.: Berries: emerging impact on cardiovascular health. Nutr. Rev., 2010; 68:168-177.
  21. Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food. 2010;13(2):255-69.
  22. Bijak M, Bobrowski M, Borowiecka M, Podsędek A, Golański J, Nowak P.Anticoagulant effect of polyphenols-rich extracts from black chokeberry and grape seeds. Fitoterapia. 2011;82(6):811-7.

  

Blood pressure lowering:

  1. Naruszewicz M., Daniewski M., Łaniewska I., Pikto-Pietkiewicz W., Millo B., Zapolska-Downar D.: Effect of anthocyanins from chokeberry (Aronia melanocarpa) on blood pressure, inflammatory mediators and cell adhesion molecules in patients with a history of myocardial infarction (MI). Atherosclerosis Suppl, 2003; 4: 143.
  2. KonczakI., Zhang W.: Anthocyanins – More Than Nature’s Colours. J. Biomed. Biotechnol., 2004;5: 239–240.
  3. Andriambeloson E., Magnier C., Haan-Archipoff G., Lobstein A, Anton R., Beretz A., Stoclet J.C., Andriantsitohaina R.: Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J. Nutr., 2007; 29: 2324-2333.
  4. Skoczyńska A., Jędrychowska I. Poręba R., Affelska A., Turczyn B.: The influence of chokeberry juice on arteria blood pressure. Pharmacol. Rep., 2007; 59: 66.
  5. Broncel M., Koziróg-Kołacińska M., Andryskowski G., Duchnowicz P., Koter-Michałak M., Owczarczyk A., Chojnowska-Jezierska J.: Effect of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin-1 and lipids in patients with metabolic syndrome. Pol. Merk. Lek , 2007; 134: 116-119.
  6. Naruszewicz M.,ŁaniewskaI., Millo B., Dłużniewski M.: Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI). Atherosclerosis, 2007; 194: 179-184.
  7. HellströmJ.K., Shikov A.N., Makarova M.N., Pihlanto A.M., Pozharitskaya O.N., Ryhänen E.L., KivijärviP.,  Makarov V.G., Pirjo H. Mattila P.H.: Blood pressure-lowering properties of chokeberry (Aronia mitchurinii, var. Viking). J. Funct. Food, 2010; 2: 163-169.
  8. Cassidy A., O’Reilly É.J., Kay C., Sampson L., Franz M., Forman J.P., Curhan G., Rimm E.B.: Habitual intake of flavonoid subclasses and incident hypertension in adults. Am. J. Clin. Nutr., 2011; 2: 338-347.
  9. Hassellund S.S., Flaa A., Sandvik L., Kjeldsen S.E., Rostrup M.: Effects of anthocyanins on blood pressure and stress reactivity: a double-blind randomized placebo-controlled crossover study. J. Hum. Hypertens., 2011;5  

 

Hypolipidemic:

  1. D.V. Rodriguez de Sotillo, M. Hadley, “Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats”, J. Nutr. Biochem. 2002: 13: 717-72.
  2. Oszmiański J., Wojdyło A.: Aronia melanocarpa phenolics and their antioxidant activity. Eur. Food Res. Technol., 2005; 221: 809-813.
  3. Vachleva-Kuzmanova S.V., Kuzmanov K., Tancheva S.,  Bechleva A.: Hypoglycemic and hypolipidemic effects of Aronia melanocarpa fruit juice in streptozotocin-induced diabetic rats. Methods Find. Exp. Clin. Pharmacol., 2007 29: 101-105.
  4. Vachleva-Kuzmanova S., Kuzmanov K., Tsanova-Savova S., Mihova V., KrasnalievI., Borisova P. et al.: Lipid-lowering effects of Aronia melanocarpa fruit juice in rats fed cholesterol-containing diets. J. Food Biochem., 2007; 31: 589-602.
  5. Vachleva-Kuzmanova S., Kuzmanov K., Mihova V.,KrasnalievI., Borisova P., Belcheva A.: Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet. Plant. Foods Hum. Nutr., 2007; 62: 19-24.
  6. Jurgoński A., Juśkiewicz J., Zduńczyk Z.: Ingestion of black chokeberry fruit extract leads to intestinal and systemic changes in a rat model of prediabetes and hyperlipidemia. Plant. Foods Hum. Nutr., 2008; 63: 176–182.
  7. Poręba R., Skoczyńska A., Gać P., Poręba M.,JedrychowskaI., Affelska-Jercha A., Turczyn B., Wojakowska A., Oszmiański J., Andrzejak R.: Drinking of chokeberry juice from the ecological farm Dzięciołowo and distensibility of brachial artery in men with mild hypercholesterolemia. Ann. Agric. Environ. Med., 2009; 16: 305-308.
  8. Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food. 2010;13(2):255-69.

 

 Antidiabetic:

  1. Jankowski A., Jankowska B., Niedworok J: Influence of anthocyanins from Aronia melanocarpa Elliot on the course of experimental diabetes. Diab. Pol., 1999; 2: 87-95.
  2.  Pawłowicz P., Wilczyński J., Stetkiewicz T.: Influence of natural anthocyanins derived from chokeberry (Aronia melanocarpa) extract on glycosylated hemoglobin level in pregnant women with insulin-dependent diabetes mellitus. Pol. J. Gyn. Invest., 2001; 3: 123-125.
  3. Niedworok J., Therapeutical properties of anthocyanins from Aronia melancarpa. Farm. Pol., 2001; 57: 719-721.
  4. Simeonov S.B., Botushanov N.P., Karahanian E.B., Pavlova M.B., Husianitis H.K., Troev D.M.: Effects of Aronia melanocarpa juice as part of the dietary regiment in patients with diabetes mellitus. Folia. Med., 2002; 44: 20-23.
  5. Vachleva-Kuzmanova S.V., Bechleva A.: Current knowledge of Aronia melanocarpa as a medical plant. Folia. Med., 2006; 48: 11-17.
  6. Ghosh D, Konishi T.: Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function.Asia.Pac.J. Clin. Nutr., 2007;16: 200-208.
  7. Vachleva-Kuzmanova S.V., Kuzmanov K., Tancheva S.,  Bechleva A.: Hypoglycemic and hypolipidemic effects of Aronia melanocarpa fruit juice in streptozotocin-induced diabetic rats. Methods Find. Exp. Clin. Pharmacol., 2007; 29: 101-105.
  8. Knekt P., Kumpulainen J., Järvinen R., Rissanen H., Heliövaara M., Reunanen A., Hakulinen T., Aromaa A.: Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr., 2007; 29: 560-568.
  9. Galvano F.,La Fauci L.,Vitaglione P., Fogliano V., Vanella L., Felgines C.: Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. Ann. Ist. Super Sanita., 2007; 43: 382-393.
  10. Ghosh D, Konishi T.: Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function.  AsiaPac J Clin Nutr. 2007;16: 200-208.
  11. Jurgoński A., Juśkiewicz J., Zduńczyk Z.: Ingestion of black chokeberry fruit extract leads to intestinal and systemic changes in a rat model of prediabetes and hyperlipidemia. Plant. Foods Hum. Nutr., 2008; 63: 176–182.
  12. Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food. 2010;13(2):255-69.

 

  

Anti-inflammatory:

  1. Naruszewicz M., Daniewski M.,ŁaniewskaI., Pikto-Pietkiewicz W., Millo B., Zapolska-Downar D.: Effect of anthocyanins from chokeberry (Aronia melanocarpa) on blood pressure, inflammatory mediators and cell adhesion molecules in patients with a history of myocardial infarction (MI). Atherosclerosis Suppl, 2003; 4: 143.
  2. Valcheva-Kuzmanova S., Borisova P., Galunska B.,KrasnalievI., Balcheva A.: Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats. Exp. Toxicol. Pathology, 2004; 56: 195-201.
  3. Ohgami K.,IlievaI., Shiratori K., Koyama Y., Jin X-H, Yoshida K., Kase S., Kitaichi N., Suzuki Y., Tanaka T., Ohno S.. Anti-inflammatory effects of aronia extract on rat endotoxin-induced uveitis. Invest. Ophthalmol & Visual Sci., 2005; 46(1): 275-281.
  4. Zielińska-Przyjemska M., Olejnik A., Dobrowolska-Zachwieja A., Grajek W.: Effects of Aronia melanocarpa polyphenols on oxidative metabolism and apoptosis of neutrophils from obese and non-obese individuals. Acta Sci. Pol., Technol. Aliment., 2007; 6: 75-87.
  5. Knekt P., Kumpulainen J., Järvinen R., Rissanen H., Heliövaara M., Reunanen A., Hakulinen T., Aromaa A.: Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr., 2007; 29: 560-568.
  6. Galvano F.,La Fauci L.,Vitaglione P., Fogliano V., Vanella L., Felgines C.: Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. Ann. Ist. Super Sanita., 2007; 43: 382-93.
  7. Jensen G.S., Wu X., Patterson K.M., Barnes J., Carter S.G., Scherwitz L., Beaman R., Endres J.R., Schauss A.G.: In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study. J. Agric. Food Chem., 2008; 56:8326-33.
  8. Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food. 2010;13(2):255-69.

 

Studies of anticancer activity:

  1. Gasiorowski K, Szyba K., Brokos B., Kołaczyńska B., Jankowiak-Włodarczyk M., Oszmiański J.: Antimutagenic activity of anthocyanins isolated from Aronia melanocarpa fruits. Cancer Lett., 1997; 119: 37-46.
  2. S. Roy, S. Khanna, H.M. Alessio, et.al. Anti-angiogenic property of edible berries, Free Radic. Res. 2002; 36: 1023-31.
  3. Malik M., Zhao C., Schoene N., Guisti M.M., Moyer M.P., Magnuson B.A. : Anthocyanin-rich extract from Aronia melanocarpa E. induces a cell cycle block in colon cancer but not normal colonic cells. Nutr Cancer, 2003; 46: 186-196.
  4. Kowalczyk E., Krzesiński P., Kura M., Szmigiel B., Błaszczyk J.: Anthocyanins in medicine. Pol. J. Pharmacol., 2003; 55: 699-702.
  5. Lazze M.C. Pizzala R., Savio M., Stivala L.A., ProsperiE., Bianchi L.: Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. Mutat. Res., 2003; 535: 103–115.
  6. Lala G., Malik M., Zhao C., He J., Kwon Y., Giusti M.M., Magnuson B.A.: Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats. Nutr. Cancer, 2006; 1: 84-93.
  7. Olas B., Kedzierska M., Wachowicz B., Stochmal A., Oleszek W., Jeziorski A., Piekarski J., Głowacki R.: Effect of aronia on thiol levels in plasma of breast cancer patients. Centr. Eur. J. Biol., 2010; 5: 38-46.
  8. Kowalczyk E., Charyk K., Fijałkowski P., Niedworok J., Błaszczyk J., Kowalski J.: Protective influence of natural anthocyanins of Aronia melanocarpa on selected parametres of antioxidative status in experimental intoxication with sulphide-2-chloroethyl-3-chloropropyl. Pol. J. Environ. Stud., 2004; 3: 339-34
  9. Zhao C., Guisti M.M., Malik M., Moyer M.P., Magnuson B.A.: Effects of commercial anthocyanin-rich extract on colonic cancer and nontumorigenic colonic cell growth. J. Agric. Food Chem., 2004; 52: 6122-6128.
  10. Hou D.X., Fujii M., Terahara N., Yoshimoto M., “Molecular mechanisms behind the chemopreventive effects of anthocyanidins”, J. Biomed. Biotechnol. 2004 (5): 321-325.
  11. Naruszewicz M., Kozłowska-Wojciechowska M.: Potential parapharmaceutical in the traditional polish diet. J. Physiol. Pharmacol., 2005; 56: 69-78.
  12. Oszmiański J., Wojdyło A.: Aronia melanocarpa phenolics and their antioxidant activity. Eur. Food Res. Technol., 2005; 221: 809-813.
  13. Bermudez-Soto M.J., Larrosa M., Garcia-Cantalejo J.M., Espin J.C., Tomas-Barberan F.A., Garcia-Conesa M.: Up-regulation of tumor suppressor carcinoembryonic antigen-related cell adhesion molecule1 inhuman colon cancer Caco-2 cells following repetitive exposure to dietary levels of a polyphenol-rich chokeberry juice. J. Nutr. Biochem., 2007; 18: 259-271.
  14. Galvano F.,La Fauci L.,Vitaglione P., Fogliano V., Vanella L., Felgines C.: Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. Ann. Ist. Super Sanita., 2007; 43: 382-93.
  15. Gescher A., Gerhäuser C. Cancer chemopreventive agents in plants – a continuing callenge. Planta Med. 2008; DOI 10.1055/s-0028-1088305

  

Detoxification & oxidative stress:

  1. 1.      Wang H., Cao G., Prior R.L.: Oxygen radical absorbing capacity of anthocyanins. J. Agric. Food Chem., 1997; 45: 304-309.
  2. Niedworok J., Therapeutical properties of anthocyanins from Aronia melancarpa. Farm. Pol., 2001; 57: 719-721.
  3. Kowalczyk E., Kopff A., Fijałkowski P., Kopff M., Niedworok J., Błaszczyk J. et al.: Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium. Acta Biochim. Pol., 2003; 50; 543-548.
  4. Lazze M.C. Pizzala R., Savio M., Stivala L.A., ProsperiE., Bianchi L.: Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. Mutat. Res., 2003; 535: 103–115.
  5. Kowalczyk E., Charyk K., Fijałkowski P., Niedworok J., Błaszczyk J., Kowalski J.: Protective influence of natural anthocyanins of Aronia melanocarpa on selected parameters of antioxidative status in experimental intoxication with sulphide-2-chloroethyl-3-chloropropyl. Pol. J. Environ. Stud., 2004; 3: 339-341.
  6. Vachleva-Kuzmanova S., Borisova P., Galunska B.,KrasnalievI., Bechleva A.: Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats. Exp. Toxicol. Pathol., 2004; 56: 195-201.
  7. Vachleva-Kuzmanova S.V., Marazova-Kuzmanova K.,KrasnalievI., Galunska B., Borisova P., Bechleva A.: Effect of Aronia melanocarpa fruit juice on indometacin-induced gastric mucosal damage and oxidative stress in rats. Exp. Toxicol. Pathology, 2005; 56: 385-392.
  8. Sueiro, L., G. G. Yousef, D. Seigler, E. G. De Mejia, M. H.Grace and M. A. Lila.:  Chemopreventive potencial of flavonoid extracts from plantation bred and wild Aronia melanocarpa (black chokeberry) fruits. J Food Sci, 2006; 71:480–488.
  9. WawerI., The Power of nature. Aronia melanocarpa. Mae’s Health and Wellness LCC,Omaha,NE,USA, 2010.
  10. Kujawska M., Ignatowicz E., Ewertowska M., Oszmiański J., Jodynis-Liebert J. Protective effect of chokeberry on chemical-induced oxidative stress in rat. Hum Exp Toxicol. 2011; 30(3):199-208.
  11. Szaefer H, Krajka-Kuźniak V, Ignatowicz E, Adamska T, Baer-Dubowska W. Chokeberry (Aronia melanocarpa) juice modulates 7,12-dimethylbenz [a] anthracene induced hepatic but not mammary gland phase I and II enzymes in female rats. Environ Toxicol Pharmacol. 2011; 31(2): 339-46.

 

 

Radioprotective properties:

  1. 1.      Wang H., Cao G., Prior R.L.: Oxygen radical absorbing capacity of anthocyanins. J. Agric. Food Chem., 1997; 45: 304-309.
  2. 2.      Andryskowski G. , Niedworok J., Maziarz Z., Małkowski B.: Protective effect of natural anthocyanin dye on experimental radiation sickness. Acta Pol. Toxycol., 1998; 6:155-162.
  3. 3.      Andryskowski G. , Niedworok J., Maziarz Z., Małkowski B.: The effect of anthocyanin dye on superoxide radical generation and chemiluminescence in animal after absorbed 4Gy dose of gamma-radiation. Pol.J. Environm., 1998; 7: 537-541.
  4. Niedworok J., Therapeutical properties of anthocyanins from Aronia melancarpa. Farm. Pol., 2001; 57: 719-721.
  5. Greul A.K. Grundmann J.U., Heinrich F., Pfitzner I., Bernhardt J., Ambach A., Biesalski H.K., Gollnick H.: Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacol. Appl. Skin Physiol., 2002, 15: 307–315.
  6. Sauvaget C., Kasagi F., WaldrenC.A.: Dietary factors and cancer mortality among atomic bomb survivors. Mutat. Res., 2004; 551: 145-152.
  7. Vachleva-Kuzmanova S.V., Bechleva A.: Current knowledge of Aronia melanocarpa as a medical plant. Folia. Med., 2006; 48: 11-17.
  8. WawerI., The Power of nature. Aronia melanocarpa. Nature’s print.UK,London, 2006.
  9. WawerI., The Power of nature. Aronia melanocarpa. Mae’s Health and Wellness LCC,Omaha,NE,USA, 2010.

 

 

Anthocyanins and neurological system:

  1. Ishige K., Schubert D., Saraga Y., “Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms”, Free Radic. Biol. Med. 2001; 30: 433-446.
  2. Sun A.Y., Simonyl A., Sun G.Y., The ‘French paradox’ and beyond: neuroprotective effects of polyphenols, Free Radic. Biol. Med. 2002; 32 314-318.
  3. Joseph J.A., Denisova N.A., Arendash G., et al., Blueberry supplementation enhances signalling and prevents behavioral deficits in an Alzheimer disease model, Nat. Neurosci. 2003: 6: 153-162.
  4. Andres-Lacueva C., Shukitt-Hale B., Galli R.L., Jauregui O., Lamuela-Raventos R.M., Joseph J.A.: Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr. Neurosci., 2005; 8: 111-120.
  5. Shukitt-Hale B., Lau F.C., Joseph J.A.:Berryfruit supplementation and the aging brain. J. Agric. Food Chem., 2008; 56: 636–641.
  6. Kalt W., Blumberg J.B., McDonald J.E., Vinqvist-Tymchuk M.R., Fillmore S.A.E., Graf B.A., O’Leary J.M., Milbury P.E.: Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. J. Agric. Food Chem., 2008; 56: 705–712.

 

 

In Polish language:

  1. Andryskowski G., Niedworok J., Grześków J., Maziarz Z., Małkowski B., Tryniszewski W., Rożej A.: Naturalne antocyjany w ochronie radiologicznej. Współcz. Onkol., 2000; 4: 269-272.
  2. Jankowski A., Jankowska B., Niedworok J.: Wpływ antocyjanin z aronii czarnoowocowej na przebieg doświadczalnego zapalenia trzustki. Pol. Merkur. Lek., 2000; 8: 395-398.
  3. Niedworok J., Brzozowski F.: Badania nad biologicznymi i fitoterapeutycznymi właściwościami antocyjanin aronii czarnoowocowej. Post. Fitoter., 2001; 1: 20-24.
  4. Niedworok J.: Właściwości lecznicze antocyjanin z aronii czarnoowocowej. Farm. Pol., 2001; 15: 719-722.
  5. Kowalczyk E., Jankowski A., Niedworok J., Śmigielski J.: Wpływ antocyjanin z aronii czarnoowocowej na angiogenezę u zwierząt otrzymujących kadm. Farm Pol., 2002; 20: 940-941.
  6. Kowalczyk E., Krzesiński P., Fijałkowski P., Błaszczyk J., Kowalski J.: Wykorzystanie antocyjanin w terapii chorób układu sercowo-naczyniowego. Pol. Merk. Lek., 2005; 109: 108-110.
  7. Kowalczyk E., Fijałkowski P., Kura M., Krzesiński P., Błaszczyk J., Kowalski J., Śmigielski J., Rutkowski M., Kopff M.: Wpływ antocyjanin z aronii czarnoowocowej na wybrane parametry stresu oksydacyjnego i zawartość mikroelementów u mężczyzn z hipercholesterolemią. Pol. Merk. Lek., 2005; 113: 651-653.
  8. Wawer I.: Aronia – polski paradoks. Agropharm S.A. Warszawa 2006.
  9. Zielińska-Przyjemska M., Olejnik A., Grajek W.: Wpływ soku z buraka ćwikłowego i aronii in vitro na na metabolizm tlenowy i apoptozę ludzkich granulocytów obojętnochłonnych. Żywność. Nauka. Technologia. Jakość, 2007; 2: 174-185.
  10. Sikora J., Markowicz M., Mikiciuk-Olasik E.: Rola i właściwości lecznicze aronii czarnoowocowej w profilaktyce chorób cywilizacyjnych. Bromat. Chem. Toksykol., 2009, 1: 10-17.
  11. Fołta M., Bartoń H., Paśko P., Zagrodzki P., Krośniak M., Zachwieja Z.: Stres oksydacyjny i zaburzenia metaboliczne u szczurów w modelu wysokofruktozowym. Cz.II. Wpływ soku z aronii na wybrane parametry biochemiczne osocza. Bromat. Chem. Toksykol., 2009; 3: 842-847.